Bioengineering Research of Chronic Wounds

Bioengineering Research of Chronic Wounds Author Amit Gefen
ISBN-10 9783642005343
Year 2009-11-18
Pages 449
Language en
Publisher Springer Science & Business Media

Pressure-related chronic wounds are an important health concern that affects millions of patients and accumulates billions in annual costs. These wounds may occur when soft tissues are mechanically compressed between bony prominences and a supporting surface. This book gives a complete and quantitative explanation of the mechanobiology which causes chronic wounds. The reviews give an overall picture on all length scales of the phenomenon, starting from musculoskeletal biomechanics to the modeling of soft tissues and their interaction with bones. At the microscopic levels, it thoroughly reviews experiments and modeling of cellular forces and molecular processes that occur during injury and healing, including the integrity of living cells subjected to sustained mechanical forces and deformations. The results allow a complete picture of the tolerance of human tissues to sustained loads, and an understanding of the risk for onset of chronic wounds. Hence, this book is also valuable for all professionals involved in the prevention and treatment of chronic wounds.

Bioengineering in Wound Healing

Bioengineering in Wound Healing Author Martin L Yarmush
ISBN-10 9789813144590
Year 2017-03-24
Pages 396
Language en
Publisher World Scientific

What is a wound, how does it heal, and how can we prevent scarring? The concept of wound healing has puzzled humans even before the advent of modern medicine. In recent years, bioengineering has tackled the problems of cancer, tissue engineering and molecular manufacturing. The broad spectrum of technologies developed in these fields could potentially transform the wound care practice. However, entering the world of wound healing research is challenging — a broad spectrum of knowledge is required to understand wounds and improve healing. This book provides an essential introduction of the field of wound healing to bioengineers and scientists outside the field of medicine. Written by leading researchers from various fields, this book is a comprehensive primer that gives readers a holistic understanding of the field of wound biology, diagnostics and treatment technologies. Contents:Scarless Tissue Regeneration (Alexander Golberg)Anatomy of the Human Skin and Wound Healing (Amit Sharma, Labib R Zakka and Martin C Mihm Jr)Deprived and Enriched Environments: How Sensory Stimulation Affects Wound Healing (Jonathan G Fricchione and John B Levine)Models of Ischemic and Vascular Wounds (Michael T Watkins and Hassan Albadawi)Developmental Biology of Skin Wound Healing: On Pathways and Genes Controlling Regeneration Versus Scarring (Sarah Susan Kelangi and Marianna Bei)Nutrition, Metabolism, and Wound Healing Process (Yong-Ming Yu and Alan J Fischman)Polarization Sensitive Optical Coherence Tomography for Imaging of Wound Repair (Martin Villiger and Brett E Bouma)Functional Imaging of Wound Metabolism (Jake Jones, Vasily Belov and Kyle P Quinn)Functional Skin Substitutes — The Intersection of Tissue Engineering and Biomaterials (Kevin Dooley, Julie Devalliere and Basak Uygun)Biomaterial-Based Systems for Pharmacologic Treatment of Wound Repair (Mara A Pop, Julia B Sun and Benjamin D Almquist)Laser Tissue Welding in Wound Healing and Surgical Repair (Russell Urie, Tanner Flake and Kaushal Rege)Bioprinting for Wound Healing Applications (Aleksander Skardal, Sean Murphy, Anthony Atala and Shay Soker)Electroporation Applications in Wound Healing (Laure Gibot, Tadej Kotnik and Alexander Golberg) Readership: Bioengineers, scientists, researchers and graduate students outside the field of medicine.

The Care of Wounds

The Care of Wounds Author Carol Dealey
ISBN-10 9781118276181
Year 2012-01-31
Pages 256
Language en
Publisher John Wiley & Sons

The Care of Wounds addresses all aspects of holistic wound management. The fourth edition of this successful clinical text continues to reflect current research and evidence-based practice, while incorporating the considerable developments which have occurred in wound care practice since the previous edition. It includes chapters on the physiology of wound healing, general principles of wound management, wound management products, and the management of patients with both acute and chronic wounds. The title is an essential read for all nurses and healthcare professionals working in the field of tissue viability and wound healing. Comprehensive and clinically-oriented Examines best practice in wound management Incorporates national and international clinical guidelines where applicable Superbly illustrated with full colour throughout

Mechanical and Chemical Signaling in Angiogenesis

Mechanical and Chemical Signaling in Angiogenesis Author Cynthia Reinhart-King
ISBN-10 9783642308567
Year 2012-09-14
Pages 282
Language en
Publisher Springer Science & Business Media

This volume describes and discusses recent advances in angiogenesis research. The chapters are organized to address all biological length scales of angiogenesis: molecular, cellular and tissue in both in vivo and in vitro settings. Specific emphasis is given to novel methodologies and biomaterials that have been developed and applied to angiogenesis research. Angiogenesis experts from diverse fields including engineering, cell and developmental biology, chemistry and physics will be invited to contribute chapters which focus on the mechanical and chemical signals which affect and promote angiogenesis.

The Mechanobiology and Mechanophysiology of Military Related Injuries

The Mechanobiology and Mechanophysiology of Military Related Injuries Author Amit Gefen
ISBN-10 9783319330129
Year 2016-03-31
Pages 333
Language en
Publisher Springer

This book provides a state-of-the-art update, as well as perspectives on future directions of research and clinical applications in the implementation of biomechanical and biophysical experimental, theoretical and computational models which are relevant to military medicine. Such experimental and modeling efforts are helpful, on the one hand, in understanding the aetiology, pathophysiology and dynamics of injury development and on the other hand in guiding the development of better equipment and protective gear or devices that should ultimately reduce the prevalence and incidence of injuries or lessen their hazardous effects. The book is useful for military-oriented biomedical engineers and medical physicists, as well as for military physiologists and other medical specialists who are interested in the science and technology implemented in modern investigations of military related injuries.

Platelet Rich Plasma

Platelet Rich Plasma Author José Fábio Santos Duarte Lana
ISBN-10 9783642401176
Year 2013-10-29
Pages 360
Language en
Publisher Springer Science & Business Media

Platelet-Rich Plasma (PRP) has gained tremendous popularity in recent years as a treatment option for specialties including Orthopedics, Dentistry, Sports Medicine, Otorhinolaryngology, Neurosurgery, Ophthalmology, Urology, Vascular, Cardiothoracic and Maxillofacial Surgery, and Veterinarian Medicine. Nowadays, PRP and Stem Cell Science have added an exciting dimension to tissue repair. This book begins by giving the reader a broad overview of current progress as well as a discussion of the technical aspects of preparation and therapeutic use of autologous PRP. It is followed by a review of platelet structure, function and major growth factors in PRP (PDGF and TGFβ).The third chapter outlines the basic principles of biochemical cellular metabolism that increases the efficacy of PRP. Analogous to the preparation of soil for a garden, restoring cellular health should be the first consideration in Regenerative Medicine. Standardization of PRP preparation to clinical use still remains a challenging prospect. In this sense, a feasible strategy for studying PRP preparation is illustrated, which also allows to modulate and tailor the quality of PRP for further clinical applications. The science behind PRP and stem cells, on tissue regeneration, cell proliferation and mesenchyme stem-cells are emphasized and reviewed. Various specific uses of PRP are described with detailed illustrations of various personal experiences mainly in orthopedic injuries, ligament and tend on repair, degenerative diseases, sports medicine, chronic wound healing as well as rehabilitation aspects in tendinopathy. Expertly written by leading scientists in the field, this book provides for beginners and experienced readers scientific fundamentals, the state of art of PRP, specific uses and personal experiences with a practical approach and reference for current trends in use. Finally, this book paves the way for future developments.

Biomaterials and bioengineering handbook

Biomaterials and bioengineering handbook Author Donald Lee Wise
ISBN-10 0824703189
Year 2000
Pages 920
Language en
Publisher CRC

This reference reports on progress in the development of materials used in or on the human body, ranging from biopolymers used in controlled-release drug delivery systems and prosthetic devices to metals used in bone repair and 'plastics' used in absorbable mechanisms such as sutures. A broad panel of engineers, designers, materials scientists, and physicians provide a multidimensional and interdisciplinary approach for this encyclopedic resource, offering highly detailed descriptions of actual clinical applications of biomaterials. Examines both research and clinical issues surrounding traditional and emerging biomaterials from a variety of professional perspectives.

Regenerative Biology and Medicine

Regenerative Biology and Medicine Author David L. Stocum
ISBN-10 9780123848611
Year 2012-06-07
Pages 474
Language en
Publisher Academic Press

Regenerative Biology and Medicine, Second Edition — Winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — discusses the fundamentals of regenerative biology and medicine. It provides a comprehensive overview, which integrates old and new data into an ever-clearer global picture. The book is organized into three parts. Part I discusses the mechanisms and the basic biology of regeneration, while Part II deals with the strategies of regenerative medicine developed for restoring tissue, organ, and appendage structures. Part III reflects on the achievements of regenerative biology and medicine; future challenges; bioethical issues that need to be addressed; and the most promising developments in regenerative medicine. The book is designed for multiple audiences: undergraduate students, graduate students, medical students and postdoctoral fellows, and research investigators interested in an overall synthesis of this field. It will also appeal to investigators from fields not directly related to regenerative biology and medicine, such as chemistry, informatics, computer science, mathematics, physics, and engineering. Highly Commended 2013 BMA Medical Book Award for Medicine Includes coverage of skin, hair, teeth, cornea, and central neural tissues Provides description of regenetive medicine in digestive, respiratory, urogenital, musculoskeletal, and cardiovascular systems Includes amphibians as powerful research models with discussion of appendage regeneration in amphibians and mammals


Bioengineering Author Audric Garcia
ISBN-10 UOM:39076002900400
Year 2010
Pages 218
Language en
Publisher Nova Science Publishers

This book summarises recent progress of newly developed bioengineering technology, such as low-energy ion beam bioengineering (IBBE). Low-energy IBBE has demonstrated powerful impacts and highly potential applications on biology, agriculture, horticulture and life science. Over the years, many shell finite elements have been developed for applications in aerospace, automotive and shipbuilding industries. A review of the development and application of triangular shell finite elements is also included in this book. In addition, the challenge of bioengineering glass-ceramics and ceramics for the fabrication of dental restorations is to fulfil the needs of patients. The authors report on methods for developing materials that show a combination of different properties. New methods to measure some essential properties of tissue-engineered cartilage are examined, as well as the types of gene assembly in terms of metabolic engineering, and the principle of and actual protocol for the Ordered Gene Assembly in B. subtilis (OGAB). Furthermore, the use of human embryos and foetuses for the advancement of fundamental science and for the production of life-saving vaccines has had a significant historical importance. Cellular therapy using embryonic and fetal tissue has become a very prominent subject in the 21st century in the search of new treatments. This book clarifies some definitions of newly used terms for embryonic and foetal cells, describes world-wide policy on voluntary interruption of pregnancy and elaborates on the history for legal use for both embryonic and foetal issues. Some bioengineering approaches for the treatment of severe pressure ulcers (PU) are examined in this book as well.

Chronic Wound Healing

Chronic Wound Healing Author Raj Mani
ISBN-10 UOM:39015042794662
Year 1999-01
Pages 185
Language en
Publisher Bailliere Tindall

This concise and fully illustrated book examines the range of measurement techniques available today and assesses their significance and role in the management of patients, as well as their use to the researcher in wound healing.

The Epidermis in Wound Healing

The Epidermis in Wound Healing Author David T. Rovee
ISBN-10 9780203495322
Year 2003-12-29
Pages 408
Language en
Publisher CRC Press

New biological techniques and a revival of interest in both acute and chronic wound healing have led to an enormously improved understanding of the cellular and chemical complexities of the healing process. Exciting developments in the evolution of epidermal biology are creating new opportunities for research and clinical applications in wound healing. Edited by an expert team of researchers and clinicians, The Epidermis in Wound Healing combines current information with the latest research results to provide a complete picture of the most recent advances in the field. The book focuses on biological advances that improve knowledge and stimulate development in wound therapy. The chapter authors address quantifying repair in the epidermis, biological and clinical elements of wound healing, state-of-the-art approaches to understanding and treating wounds, and gene therapy during wound repair. A discussion on the underlying chemistry of acute and chronic healing describes the special challenges presented by chronic wounds. Featuring the most up-to-date information available, the book chronicles the progress and practices in the field of wound therapy over the past 30 years. This reference will be an essential tool in the generation of innovations and applications in epidermal biology.

Stem Cell Research Trends

Stem Cell Research Trends Author Josse R. Braggina
ISBN-10 UVA:X030262805
Year 2007-01-01
Pages 349
Language en
Publisher Nova Science Pub Incorporated

Among the many applications of stem cell research are nervous system diseases, diabetes, heart disease, auto-immune diseases as well as Parkinson's disease, end-stage kidney disease, liver failure, cancer, spinal cord injury, multiple sclerosis, Parkinson's disease, and Alzheimer's disease. Stem cells are self-renewing, unspecialised cells that can give rise to multiple types all of specialised cells of the body. Stem cell research also involves complex ethical and legal considerations since they involve adult, foetal tissue and embryonic sources. This book presents important research from around the globe.